Best treatment for perimenopause symptoms: a full guide

Perimenopause varies because of erratic estrogen swings and declining progesterone; individualized, patient-centered plans outperform one-size-fits-all care. For hot flashes and night sweats, systemic hormone replacement therapy—especially transdermal estradiol with endometrial protection like micronized progesterone—is the most effective option, and the guide maps systemic, local, lifestyle, and functional approaches to inform your questions.